研究一覧

現在小児集中治療科では、下記の臨床研究を実施しています。臨床研究では、患者さんの日常診療で得られた情報を匿名化した上で利用させていただきます。 研究の計画や内容などについて詳しくお知りになりたい方、ご質問がある方はご連絡ください。

研究名	説明文書
小児心肺蘇生の質に関する多施設共同観察試験 (pedRES-Q)	PDF
日本における重症・中等症小児COVID-19登録及びMIS-C全国調査共同研究	PDF
患者情報システムを用いた集中治療室の機能評価	PDF
小児急性呼吸窮迫症候群(PARDS)；アジアにおける前方視的多施設研究(PARDS PRO-ASIA study)	PDF
体外式膜型人工肺中の溶血と血中一酸化炭素ヘモグロビン濃度の相関性の検討	PDF
小児心臓血管外科術後患者における横隔膜萎縮と抜管失敗予測に関する研究	PDF
多施設共同気管挿管レジストリー NEAR4KIDS (National Emergency Airway Registry for Children)	PDF
小児集中治療室におけるQuality of Dying and Death(PICU-QODD)医療者評価用尺度の日本語版開発と信頼性・妥当性の検証	PDF

論文一覧

2023年

Time Course of Serum Cytokine Level Changes within 72 h after Onset in Children with Acute Encephalopathy and Febrile Seizures. Tomioka K, Nishiyama M, Tokumoto S, Yamaguchi H, Aoki K, Seino Y, Toyoshima D, et al. BMC Neurology 2023;23(1):7. https://doi.org/10.1186/s12883-022-03048-8.

Early Metabolic Derangements and Unfavorable Outcomes in Pediatric Traumatic Brain Injury: A Retrospective Multi-Center Cohort Study. Yao S, Chong SL, Allen JC, Dang H, Ming M, Chan LCN, Gan CS, et al. Translational Pediatrics 2023;12(3):344-353. https://doi.org/10.21037/tp-22-443.

Annual patterns in the outcomes and post-arrest care for pediatric out-of-hospital cardiac arrest: A nationwide multicenter prospective registry in Japan. Matsui S, Kurosawa H, Hayashi T, Takei H, Tanizawa N, Ohnishi Y, Murata S, et al. Resuscitation 2023;191:109942. https://doi.org/10.1016/j.resuscitation.2023.109942

Machine learning predicts blood lactate levels in children after cardiac surgery in paediatric ICU. Sughimoto K, LevmanJ, Baig F, Berger D, Oshima Y, Kurosawa H, Aoki K, et al. Cardiology in the Young 2023;33(3):388-395. https://doi.org/10.1017/S1047951122000932

Early steroid pulse therapy for children with suspected acute encephalopathy: An observational study. IshidaY, Nishiyama M, Yamaguchi H, Tomioka K, Takeda H, Tokumoto S, Toyoshima D, et al. Medicine(Baltimore) 2021;100(30):e26660. https://doi.org/10.1097/MD.0000000000026660

The respiratory elastance ratio in thanatophoric dysplasia: A case report. Aoki K , Kurosawa H, Shirasawa A, ShiomiY, Seino Y. Pediatric International 2023;65(1):e15534. https://doi.org/10.1111/ped.15534

The Japanese Pediatric Continuous Renal Replacement Therapy (jpCRRT) Registry: Study Protocol. Haga T, Tani M, Oi T, Sakihama H, Sasaki K, Fujiwara N, Miyaji M, et al. Annals of Clinical Epidemiology 2023;5(4):121–126. https://doi.org/10.37737/ace.23016

2022年

Changes in Pediatric Intensive Care Unit Cases due to the Novel Coronavirus. Kurosawa H, Koizumi T, Kawasaki T, Takeuchi M, Shime N. Pediatrics International 2022;64(1): e15019. https://doi.org/10.1111/ped.15019.

The Association between Prehospital Vital Signs of Children and Their Critical Clinical Outcomes at Hospitals. Kurosawa H, Shiima Y, Miyakoshi C, Nezu M, Someya M, Yoshida M, Nagase H, Nozu K, Kosaka Y, Iijima K. Scientific Reports 2022;12(1):5199. https://doi.org/10.1038/s41598-022-09271-0.

Target Temperature Management and Survival with Favorable Neurological Outcome After Out-of-Hospital Cardiac Arrest in Children: A Nationwide Multicenter Prospective Study in Japan. Matsui S, Hirayama A, Kitamura T, Sobue T, Hayashi T, Takei H, Tanizawa N, et al. Therapeutic Hypothermia and Temperature Management 2022;12(1):16-23. https://doi.org/10.1089/ther.2020.0050.

Outcomes of Pediatric Patients in Secondary Transport to Tertiary Hospital: A Retrospective Observational Study. Nezu M, Shiima Y, Kurosawa H, Miyakoshi C. Pediatric Emergency Care 2022;38(6):283–289. https://doi.org/10.1097/PEC.0000000000002711.

Ethical and Social Issues for Health Care Providers in the Intensive Care Unit during the Early Stages of the COVID-19 Pandemic in Japan: A Questionnaire Survey. Seino Y, Aizawa Y, Kogetsu A, Kato K. Asian Bioethics Review 2022;14(2):115-131. https://doi.org/10.1007/s41649-021-00194-y.

小児開心術の術後急性腎障害に対するハプトグロビン製剤投与法の検討. 三坂勇介，長谷川智巳. 日本集中治療医学会雑誌 2022;29(1):8–14. https://doi.org/10.3918/jsicm.29_8

重症百日咳のECMO管理中に二次性血栓性微小血管症の合併が疑われた乳児例. 潮見祐樹, 青木一憲, 黒澤寛史. 日本集中治療医学会雑誌 2022;29(5):533-537. https://doi.org/10.3918/jsicm.29_533

COVID-19パンデミック下のPICU面会制限の影響と遠隔面会の有用性：単施設調査紙研究. 坂本佳津子, 制野勇介, 細川つばさ, 植野杏樹, 前田佳子, 越後尚子, 黒澤寛史. 日本集中治療医学会雑誌 2022;29(5):555–558. https://doi.org/10.3918/jsicm.2200001

2021年

Closed-PICU Perioperative Management of Congenital Tracheal Stenosis. Aoki K, Kurosawa H, Seino Y, Morita K, Matsuhisa H, Oshima Y. Pediatrics International 2021;64(1): e15085. https://doi.org/10.1111/ped.15085.

Traumatic Brain Injury Outcomes in 10 Asian Pediatric ICUs: A Pediatric Acute and Critical Care Medicine Asian Network Retrospective Study. Chong SL, Dang H, Ming M, Mahmood M, Zheng CQS, Gan CS, Lee OPE, et al. Pediatric Critical Care Medicine 2021;22(4):401–411. https://doi.org/10.1097/PCC.0000000000002575.

Early Coagulopathy in Pediatric Traumatic Brain Injury: A Pediatric Acute and Critical Care Medicine Asian Network (PACCMAN) Retrospective Study. Chong SL, Ong GYK, Zheng CQ, Dang H, Ming M, Mahmood M, Chan LCN, et al. Neurosurgery 2021;89(2):283–290. https://doi.org/10.1093/neuros/nyab157.

Early Posttraumatic Seizures in Pediatric Traumatic Brain Injury: A Multicenter Analysis. Chong SL, Qian S, Yao SHW, Allen JC, Dang H, Chan LCN, Ming M, et al. Journal of Neurosurgery Pediatrics 2021;29(2):225-231. https://doi.org/10.3171/2021.8.PEDS21281.

Conventional Risk Prediction Models Fail to Accurately Predict Mortality Risk among Patients with Coronavirus Disease 2019 in Intensive Care Units: A Difficult Time to Assess Clinical Severity and Quality of Care. Endo H, Ohbe H, Kumasawa J, Uchino S, Hashimoto S, Aoki Y, Asaga T, et al. Journal of Intensive Care Medicine 2021;9(1):42. https://doi.org/10.1186/s40560-021-00557-5.

A Case of Infant Intracranial Hemorrhage Using an Infrared Pupillometer. Kaneko N, Aoki K, Kurosawa H. Pediatrics International 2021;63(4):470–472. https://doi.org/10.1111/ped.14433.

Successful Resuscitation with Shallow Chest Compression Depth: A Pediatric Case. Miyashita N, Kurosawa H, Aoki K. Pediatrics International 2021;63(12):1524–1526. https://doi.org/10.1111/ped.14641.

Prediction of AESD and Neurological Sequelae in Febrile Status Epilepticus. Nishiyama M, Ishida Y, Yamaguchi H, Tokumoto S, Tomioka K, Hongo H, Toyoshima D, et al. Brain & Development 2021;43(5):616–625. https://doi.org/10.1016/j.braindev.2021.01.004.

Age-Specific Dose Regimens of Dexmedetomidine for Pediatric Patients in Intensive Care Following Elective Surgery: A Phase 3, Multicenter, Open-Label Clinical Trial in Japan. Takeuchi M, Nemoto S, Suzuki Y, Takahashi N, Takenaka N, Takata A, Kobayashi M. Pediatric Critical Care Medicine 2021;22(11):e546-e557. https://doi.org/10.1097/PCC.0000000000002730.

Changes Adopted in Asian Pediatric Hospitals during the COVID-19 Pandemic: A Report from the Pediatric Acute and Critical Care COVID-19 Registry of Asia. Wong JJM, Abbas Q, Anantasit N, Shimizu N, Malisie RF, Dang H, Xu F, et al. Pediatric Critical Care Medicine 2021;11(3):221-225. https://doi.org/10.1055/s-0040-1722340.

Growth and Differentiation Factor-15 as a Potential Prognostic Biomarker for Status-Epilepticus-Associated-with-Fever: A Pilot Study. Yamaguchi H, Nishiyama M, Tomioka K, Hongo H, Tokumoto S, Ishida Y, Toyoshima D, et al. Brain & Development 2021;44(3):210-220. https://doi.org/10.1016/j.braindev.2021.10.003.

Elevated Cytokine, Chemokine, and Growth and Differentiation Factor-15 Levels in Hemorrhagic Shock and Encephalopathy Syndrome: A Retrospective Observational Study. Yamaguchi H, Nishiyama M, Tokumoto S, Ishida Y, Tomioka K, Aoki K, Seino Y, et al. Cytokine 2021;137:155324. https://doi.org/10.1016/j.cyto.2020.155324.

遠心型血液成分分離装置を用いて血漿交換を安全に施行できた血栓性血小板減少性紫斑病の小児例. 當間圭一郎, 制野勇介, 宮下徳久, 長井勇樹, 青木一憲, 長谷川智巳, 黒澤寛史. 日本集中治療医学会雑誌 2021;28(6):556–557. https://doi.org/10.3918/jsicm.28_556

2020年

The Prevalence and Characteristics of Rapid Response Systems in Hospitals with Pediatric Intensive Care Units in Japan and Barriers to Their Use. Haga T, Kurosawa H, Maruyama J, Sakamoto K, Ikebe R, Tokuhira N, Takeuchi M. International Journal for Quality in Health Care 2020,32(5):325-331. https://doi.org/10.1093/intqhc/mzaa040.

The Japanese Intensive Care PAtient Database (JIPAD): A National Intensive Care Unit Registry in Japan. Irie H, Okamoto H, Uchino S, Endo H, Uchida M, Kawasaki T, Kumasawa J, et al. Journal of Critical Care 2020;55:86–94. https://doi.org/10.1016/j.jcrc.2019.09.004.

Thiamylal Anaesthetic Therapy for Febrile Refractory Status Epilepticus in Children. Ishida Y, Nishiyama M, Yamaguchi H, Tomioka K, Tanaka T, Takeda H, Tokumoto S, et al. Seizure 2020;80:12–17. https://doi.org/10.1016/j.seizure.2020.03.012.

Survey of Analgesia and Sedation in Pediatric Intensive Care Units in Japan. Koizumi T, Kurosawa H. Pediatrics International 2020;62(5):535–541. https://doi.org/10.1111/ped.14139.

Pulmonary Hypertension Related to Hereditary Folate Malabsorption in an Infant. Miyashita N, Kurosawa H, Yamashita Y, Miki Y, Ishida T. Pediatrics International 2020;62(9):1119–1120. https://doi.org/10.1111/ped.14266.

小児大動脈弓再建術後の声帯エコー. 吉田美苗, 長谷川智巳, 金子尚樹, 黒澤寛史. 日本集中治療医学会雑誌 2020;27(2):104–108. https://doi.org/10.3918/jsicm.27_104

末梢静脈挿入式中心静脈カテーテルの血管穿孔を認めた右肺無形成の乳児例. 長井勇樹, 長谷川智巳, 山本和宏, 制野勇介, 青木一憲, 黒澤寛史. 日本集中治療医学会雑誌 2020;27(5):409–410. https://doi.org/10.3918/jsicm.27_409

小児声帯麻痺に対する声帯エコー評価の有用性. 金子尚樹, 長谷川智巳, 吉田美苗, 黒澤寛史. 2020. 日本集中治療医学会雑誌 2020;27(6):453–458. https://doi.org/10.3918/jsicm.27_453

ファロー四徴症術後遠隔期に診断された特発性肺ヘモジデローシスの一例. 山下由理子,長谷川智巳, 長井勇樹, 制野勇介, 青木一憲, 津田雅世, 田中亮二郎, 黒澤寛史. 日本集中治療医学会雑誌 2020;27(6):472-476.https://doi.org/10.3918/jsicm.27_472

食道異物を契機に発見された右鎖骨下動脈起始異常. 山本和宏, 長谷川智巳, 長井勇樹, 制野勇介, 青木一憲, 黒澤寛史. 日本小児科学会雑誌. 2020;124(1):50–54

新興・再興感染症対策小委員会およびCOVID-19 ワーキンググループ活動中間報告. 黒澤寛史. 日本小児科学会雑誌 2020;124(5):918–921.

2019年

Location of Arrest and Survival from out-of-Hospital Cardiac Arrest among Children in the Public-Access Defibrillation Era in Japan. Matsui S, Kitamura T, Sado J, Kiyohara K, Kobayashi D, Kiguchi T, Nishiyama C, et al. Resuscitation 2019;140:150–158. https://doi.org/10.1016/j.resuscitation.2019.04.045.

End-of-Life Care in the Pediatric Intensive Care Unit: Survey in Japan. Seino Y, Kurosawa H, Shiima Y, Niitsu T. Pediatrics International 2019;61(9):859–864. https://doi.org/10.1111/ped.13924.

Bedside Ultrasound in the Pediatric Intensive Care Unit: Newer Uses. Shiomi Y, Kurosawa H. Current Pediatrics Reports 2019;7:145–151. https://doi.org/10.1007/s40124-019-00203-7.

Predicting the Outcomes of Targeted Temperature Management for Children with Seizures And/or Impaired Consciousness Accompanied by Fever without Known Etiology. Tanaka T, Nagase H, Yamaguchi H, Ishida Y, Tomioka K, Nishiyama M, Toyoshima D, et al. Brain & Development 2019;41(7):604–613. https://doi.org/10.1016/j.braindev.2019.03.007.

Detailed Clinical Course of Fatal Acute Encephalopathy in Children. Tomioka K, Nishiyama M, Nagase H, Ishida Y, Tanaka T, Tokumoto S, Yamaguchi H, et al. Brain & Development 2019;41(8):691-698. https://doi.org/10.1016/j.braindev.2019.04.012.

Nonconvulsive Seizure Detection by Reduced-Lead Electroencephalography in Children with Altered Mental Status in the Emergency Department. Yamaguchi H, Nagase H, Nishiyama M, Tokumoto S, Ishida Y, Tomioka K, Tanaka T, et al. The Journal of Pediatrics 2019;207:213–219 e3. https://doi.org/10.1016/j.jpeds.2018.11.019.

Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion Accompanied by Takotsubo Cardiomyopathy. Yamaguchi H, Nagase H, Yoshida S, Tokumoto S, Hayashi K, Toyoshima D, Kurosawa H, Tanaka T, Maruyama A, Iijima K. Brain & Development 2019;41(3):305–309. https://doi.org/10.1016/j.braindev.2018.10.002.

2018年

Successful Use of Automated External Defibrillation in a 1-Month-Old Infant. Aoki K, Kurosawa H. Pediatrics International 2018;60(7):670–672. https://doi.org/10.1111/ped.13597.

Ultrasonographic Assessment of Vocal Cord Paralysis in an Infant after Cardiovascular Surgery. Hasegawa T, Masui M, Kurosawa H. Journal of Pediatric Cardiology and Cardiac Surgery 2018;2(2):101–103. https://doi.org/10.24509/jpccs.180207.

Characterization of Pediatric In-Hospital Cardiopulmonary Resuscitation Quality Metrics Across an International Resuscitation Collaborative. Niles DE, Duval-Arnould J, Skellett S, Knight L, Su F, Raymond TT, Sweberg T, et al. Pediatric Critical Care Medicine 2018;19(5):421–432. https://doi.org/10.1097/PCC.0000000000001520.

Fosphenytoin vs. Continuous Midazolam for Pediatric Febrile Status Epilepticus. Nishiyama M, Nagase H, Tomioka K, Tanaka T, Yamaguchi H, Ishida Y, Toyoshima D, et al. Brain & Development 2018;40(10) 884–890. https://doi.org/10.1016/j.braindev.2018.08.001.

Acute Focal Bacterial Nephritis Characterized by Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion. Yamaguchi H, Nagase H, Ito Y, Matsunoshita N, Mizutani M, Matsushige T, Ishida Y, et al. Journal of Infection and Chemotherapy 2018;24(11):932–935. https://doi.org/10.1016/j.jiac.2018.04.007.

A型インフルエンザに罹患しリン酸オセルタミビルを内服後、十二指腸潰瘍を発症し出血性ショックを来たした幼児の2例. 増井美苗, 黒澤寛史, 笠井正志, 大片祐一, 福澤宏明, 前田貢作. 日本小児救急医学会雑誌 2018;17(1):69–72.

2017年

The Effectiveness of Remote Facilitation in Simulation-Based Pediatric Resuscitation Training for Medical Students. Ohta K, Kurosawa H, Shiima Y, Ikeyama T, Scott J, Hayes S, Gould M, Buchanan N, Nadkarni V, Nishisaki A. Pediatric Emergency Care 2017;33(8):564–569. https://doi.org/10.1097/PEC.0000000000000752.